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MRAでDKD患者の動脈壁肥厚、左室線維化抑制
Mineralocorticoid Receptor Antagonism Prevents Aortic Plaque Progression and Reduces Left Ventricular Mass and Fibrosis in Patients With Type 2 Diabetes and Chronic Kidney Disease: The MAGMA Trial. Circulation. 2024 Aug 12. doi: 10.1161/CIRCULATIONAHA.123.067620. Epub ahead of print. PMID: 39129649.
24/8/12
Circulation
介入試験
MAGMA試験
2型DM+CKD 79人にスピロノラクトン12ヶ月後MRIで評価
プラセボ vs スピロノで
PWV 7.1 vs 0.8(P=0.028)
LV質量は 3.1 vs -5.8kg(P=0.001)
脈壁肥厚進展抑制、左室線維化改善をヒトで確認
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