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糖尿病性有痛性神経障害への併用効果は?

Comparison of amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin for the treatment of diabetic peripheral neuropathic pain (OPTION-DM): a multicentre, double-blind, randomised crossover trial. Lancet. 2022 Aug 27;400(10353):680-690. doi: 10.1016/S0140-6736(22)01472-6. Epub 2022 Aug 22. Erratum in: Lancet. 2022 Sep 10;400(10355):810. PMID: 36007534; PMCID: PMC9418415.

22/8/22

Lancet

介入試験

アミトリプチン(A)、プレガバリン(P)、デュロキセチン(D)の併用効果を検討。A→P、D→P、P→A群で16週後の症状は同等。

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