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アジア人
★★★
メトホルミン,糖尿病発症予防
Safety and effectiveness of metformin plus lifestyle intervention compared with lifestyle intervention alone in preventing progression to diabetes in a Chinese population with impaired glucose regulation: a multicentre, open-label, randomised controlled trial. Lancet Diabetes Endocrinol. 2023 Aug;11(8):567-577. doi: 10.1016/S2213-8587(23)00132-8. Epub 2023 Jul 3. Erratum in: Lancet Diabetes Endocrinol. 2023 Nov;11(11):e13. PMID: 37414069.
23/8/11
Lancet DE
介入試験
中国耐糖能異常1678人,Met1700mg+生活介入vs生活介入単独RCT2年.
Met群で糖尿病発症ハザード0.83(0.70-0.99)
IDDP(インド,Diabetologia 2006 (https://link.springer.com/article/10.1007/s00125-005-0097-z)ではMetの予防効果なかったので、アジア人で今回初めて
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