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やせ型MASLD、予後は肥満型と同等

de Avila L, AlNaamani KM, Papatheodoridi M, Petta S, Hagström H, Kim SU, Nakajima A, Crespo J, Castera L, Alkhouri N, Zheng MH, Treeprasertsuk S, Shalimar, Tsochatzis E, Trivikrama SK, Fan JG, Roberts SK, Alswat K, Wong VW, Yilmaz Y, Dunn W, Francque S, Cordie A, Yu ML, Ekstedt M, Goh GB, Oliveira CP, Pessoa MG, Chan WK, Castellanos Fernandez MI, Duseja A, Arab JP, Papatheodoridis G, Sebastiani G, Villela-Nogueira C, D'Ambrosio R, Lampertico P, Holleboom AG, Valsan A, El-Kassas M, Kobayashi T, Kakizaki S, Caussy C, Pearlman B, Pugliese N, Vessby J, Choudhary NS, Kawaguchi T, Russo FP, Gadano A, Diaz LA, Singal AK, Gunn N, Mauricio D, Arrese M, Fracanzani A, Lombardi R, Aghemo A, Alqahtani SA, Stepanova M, Younossi ZM; Global MASLD Study Investigators on behalf of the Global NASH/MASH Council; Ananchuensook P, Balakumaran LK, Lam B, Venu A, Pennisi G, Shang Y, Liu WY, Lee HW, Iruzubieta P, Nadeem R, Cinque F, Zoncapé M, Yang RX, Song SJ, Dunn N, Gadi Z, Yeh ML, Teh KK, Mahadeva S, Fabian LG, Almohsen A, Leite N, Xie C, Friend E, Poca M, Segrestin B, Racila A. Histologic Features and Clinical Outcomes of Lean Metabolic Dysfunction-Associated Steatotic Liver Disease. JAMA. 2026 Sep 30:e2618491. doi: 10.1001/jama.2026.18491. Epub ahead of print. PMID: 42814439; PMCID: PMC13628392.

26/9/30

JAMA

観察研究

41カ国の後ろ向き観察研究(生検確定診断)、MASLD成人1.8万人、やせ型6.7%(BMI基準)、やせ型はアジアで最多

やせ型MASLD vs 肥満型MASLDで
・全死亡 aHR 0.90
・肝関連アウトカム(肝細胞癌、②肝不全など) aHR 0.94
といずれも関連なし

進行線維化は全死亡aHR 2.10・臨床イベントaHR 3.41と強く関連
予後を左右するのは体格ではなく線維化進行度。

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